Many of the participating groups in COVID-19 Host Genetics Initiative have already submitted or published genetic findings during or in advance of. These findings should be cited as relevant to follow-up work based on specific discovered loci, even if that work may have been based on unpublished analyses of the HGI.
GenOMICC release 2
Posted date:
7th March 2022
Links:
Cases:
7,491 critically-ill cases
Controls:
48,400 controls
Genome-wide significant loci:
23 independent variants that significantly predispose to critical Covid-19
Horowitz, Kosmicki et al - REGENERON
Posted date:
16th December 2020
Links:
Cases:
52,630 individuals with COVID-19
Controls:
704,016 individuals with no record of SARS-CoV-2 infection
Genome-wide significant loci:
First publication:
ACE2
COVID-19 HGI data freeze 6 preprint
Posted date:
11th November 2021
Links:
Cases:
9,376 critically ill cases, 25,027 hospitalised cases, 125,584 reported cases of SARS-CoV-2 infection
Controls:
Up to 2,836,272 controls
Genome-wide significant loci:
23
First publication:
SFTPD, MUC5B and ACE2
COVID-19 HGI data freeze 6
COVID-19 HGI flagship paper
Posted date:
5th March 2021
Links:
Cases:
6,179 critically ill cases, 13,641 hospitalised cases, 49,562 reported cases of SARS-CoV-2 infection
Controls:
Up to 2,070,709 controls
Genome-wide significant loci:
15 genome-wide significant loci, 11 associated with severity, 4 with susceptibility
Roberts, Partha, Rhead et al. - ANCESTRY DNA 2
Posted date:
26th January 2021
Links:
Cases:
8,868 COVID-19 positives
Controls:
64,161
Genome-wide significant loci:
GALNT18 at chr 11
COVID-19 HGI data freeze 5
COVID-19 HGI data freeze 4
Genetics Of Mortality In Critical Care (GenOMICC consortium)
Posted date:
25th September 2020
Links:
Cases:
2244 critically-ill Covid-19 patients from 208 UK intensive care units (ICUs)
Controls:
population controls from UKBB, 100K Genomes, Generation Scotland
Genome-wide significant loci:
SLC6A20/CXCR6 locus, OAS1/2/3 locus, DPP9 locus, TYK2 locus, IFNAR2/IL10RB/IFNAR1 locus, HLA-G locus, CCHCR1 locus, NOTCH4 locus
First publication:
OAS1/2/3 locus, DPP9 locus, TYK2 locus, IFNAR2/IL10RB/IFNAR1 locus, HLA-G locus, CCHCR1 locus, NOTCH4 locus
Roberts, Park et al - ANCESTRY.COM
Posted date:
9th October 2020
Links:
Cases:
2407 self-reported positive nasopharyngeal swab test, 250 of those reporting hospitalization
Controls:
14,933 COVID-19 negative and 1,967 COVID-19 Cases Reporting NO Hospitalization
Genome-wide significant loci:
SLC6A20/CXCR6 locus, ABO locus, IVNS1ABP locus (male-specific), SRRM1 locus, Immunoglobulin Lambda Locus locus
First publication:
IVNS1ABP locus (male-specific), SRRM1 locus, Immunoglobulin Lambda Locus locus
Shelton, Shastri et al - 23ANDME
Posted date:
7th September 2020
Links:
Cases:
15,434 self-reported positive test result, and of those, 1,131 reported hospitalization
Controls:
101,268
Genome-wide significant loci:
SLC6A20/CXCR6 locus, ABO locus
COVID-19 HGI data freeze 3
Ellinghaus, Degenhardt et al.
Posted date:
2nd June 2020
Links:
Cases:
1,980 patients with Covid-19 respiratory failure from seven centers in Italy and Spain
Controls:
population controls from Italy and Spain (n=2205)
Genome-wide significant loci:
SLC6A20/CXCR6 locus, ABO locus
First publication:
SLC6A20/CXCR6 locus, ABO locus