COVID19-hg GWAS meta-analyses round 7

Release Date

April 8, 2022

Study Abbreviations
Full NameAbbreviation
23andMe23ANDME
24Geneticsidipaz24genetics
AArmenia_Covid-19hgArmCovid
ACCOuNTACCOuNT
Adolescent Brain and Cognitive development studyABCD
Amsterdam UMC COVID study groupAmsterdam_UMC_COVID_study_group
Ancestry Freeze FourANCESTRY_Freeze_Four
Assessment of the influence of clinical, functional, immunological and genetic factors on the severity of the course of coronavirus infection with SARS-CoV-2 and Post Covid syndromeKazCovid
Avon Longitudinal Study of Parents and Children (ALSPAC)ALSPAC_G1
Biobanque Quebec COVID19BQC19
Bonn Study of COVID19 geneticsBoSCO
CCHC COVID-19 GAWSCCHC
CGEn HostSeq - Canadian COVID-19 Human Host Genome Sequencing DatabankCGEN
CHOP CAGCHOP_CAG
Columbia University COVID19 BiobankCU
COMRI/Virology StudyCOMRI
CoronagenesCoronagenes
Covid19 Ioannina BiobankIoannina
COVID19-Host(a)geHOSTAGE
Covid19hg-CLChiCovid
deCODEDECODE
Determining the Molecular Pathways and Genetic Predisposition of the Acute Inflammatory Process Caused by SARS-CoV-2SPGRX
Egypt hgCOVID hubEgypt_hgCOVID_hub
EraCOREERACORE
Estonian BiobankEstBB
EXCEEDEXCEED
FHoGIDFHoGID
FinnGenFinnGen
French hgCOVIDFrenchCovid
Geisinger Health SystemGHS_Freeze_145
GEN-COVID, reCOVIDGENCOVID
Generation ScotlandGeneration_Scotland
Genes & HealthGNH
Genes for GoodGFG
Genetic determinants of COVID-19 complications in the Brazilian populationBRACOVID
Genetic influences on severity of COVID-19 illness in KoreaGenetics_COVID19_Korea
Genetic modifiers for COVID-19 related illnessBelCovid
Genetics of COVID-related ManifestationCorea
Genomes for LifeGCAT
Genomic epidemiology of SARS-Cov-2 and host genetics in Coronavirus Disease 2019 (COVID-19)Stanford
genomiCCgenomicc
Genomics Englandgenomicsengland100kgp
Genotek COVID-19 studyGenotek
Helix Exome+ COVID-19 PhenotypesHelix
Host genetic factors for COVID-19 severity and outcome in western Indian populationIND_GJ_COVID19
Host genetic factors in COVID-19 patients in relation to disease susceptibility, disease severity and pharmacogenomicsthaicovid
Host Genetics in COVID cohorts of mixed ancestry from MexicoMexCovid
HUNTHUNT
Iran CovidIranCovid
Japan Coronavirus TaskforceJapanTaskForce
Jordan COVID-19 Host Genomics Initiative: (JCHGI)JorCovid
Latvia COVID-19 research platformLGDB
LifelinesLifelines
MexGen-COVID InitiativeMexGen-COVID
Michigan Genomics InitiativeMGI
Million Veterans ProgramMVP
Mount Sinai Health System COVID-19 Genomics InitiativeSINAI_COVID
NCGM biobankJSA-COVID19
Netherlands Twin RegisterNTR
Pa-COVID-19Charite
Partners Healthcare BiobankPHBB
Penn Medicine BiobankPMBB
Qatar Genome ProgramQGP
SARS-CoV-2 and host genome sequencingPakCovid
Saudi Human Genome ProgramSaudiHumanGenomeProgram
Search for genomic markers predicting the severity of the response to COVID-19POLISH_COVID_WGS
Spanish COalition to Unlock Research on host GEnetics on COVID-19 (SCOURGE)SCOURGE
The Colorado Center for Personalized MedicineCCPM
The Danish Blood Donor StudyDBDS
The genetic predisposition to severe COVID-19SweCovid
The Norwegian Mother, Father and Child Cohort StudyMOBA
Tirschenreuth Study (TiKoco)TIKOCO
TOPMed CHRISTOPMed_CHRIS10K
UCLA Precision Health COVID-19 BiobankUCLA
UK BiobankUKBB
UK Blood Donors CohortINTERVAL
Val GardenaTOPMed_Gardena
Vanda COVIDVanda
Vanderbilt BiobankBioVU
Variability in immune response genes and severity of SARS-CoV-2 infection (INMUNGEN-CoV2 study)INMUNGEN_CoV2
Women's Health Genome StudyWGHS
Data Columns
Column NameDescription
#CHRchromosome
POSchromosome position
REFreference and non-effect allele
ALTalternative and effect allele (beta is for this allele)
SNP#CHR:POS:REF:ALT
all_meta_Nnumber of studies that had the variant after AF 0.001 and INFO 0.6 filtering and as such were used for the meta
all_inv_var_meta_betaeffect size on log(OR) scale
all_inv_var_meta_sebetastandard error of effect size
all_inv_var_meta_pp-value
all_inv_var_meta_casestotal number of cases
all_inv_var_meta_controlstotal number of controls
all_inv_var_meta_effectiveeffective sample size
all_inv_var_het_pp-value from Cochran's Q heterogeneity test
lmso_inv_var_betaleave-most-significant-study-out analysis effect size
lmso_inv_var_seleave-most-significant-study-out analysis standard error of effect size
lmso_inv_var_pvalleave-most-significant-study-out analysis p-value
all_meta_AFallele frequency in the meta-analysis
rsidrisd
Release Notes

Meta-analysis was done with fixed effects inverse variance weighting. Results are available in genome builds 38 and 37. An AF filter of 0.001 and an INFO filter of 0.6 was applied to each study before meta.

Extras

The downloads below do not contain the 23andMe samples (the most well-powered analyses), however the top 10K SNPs from analyses that include 23andMe samples are available here.

There are additional results with links in this README: covidhgi-freeze-7-readme.txt.

Alternatively, you can browse the Google Cloud storage bucket: gs://covid19-hg-public/freeze_7/results/20220403. You will need gsutil to list and download these files.

Included at gs://covid19-hg-public/freeze_7/results/20220403/pop_spec/sumstats are ancestry-specific (AFR, EUR, HIS/AMR) and admixed (AFR/HIS/AMR) results for hospitalization and susceptibility scans. Also the top 10k variants including 23andMe, as well as leave UKBB out results for all ancestries and EUR only.

A2_ALL_leave_23andme

Phenotype

Very severe respiratory confirmed covid vs. population

Population

All

Total Cases

18152

Total Controls

1145546

Contributing Studies
Namen_casesn_controls
ANCESTRY_Freeze_Four_EUR667113882
Amsterdam_UMC_COVID_study_group_EUR661413
BRACOVID_AMR5391149
CU_AFR1332610
CU_EUR2032149
FinnGen_FIN190278193
GENCOVID_EUR10772443
GHS_Freeze_145_EUR321108168
PMBB_AFR558622
SPGRX_EUR101302
SaudiHumanGenomeProgram_ARAB147768
Vanda_EUR58900
idipaz24genetics_EUR5975
BQC19_EUR2021366
BelCovid_EUR2971477
BioVU_EUR11768064
BoSCO_EUR195984
Charite_EUR87865
Egypt_hgCOVID_hub_MID699472
GNH_SAS19243998
HOSTAGE_EUR185012226
INMUNGEN_CoV2_EUR81723
JapanTaskForce_EAS4213317
JorCovid_MID366529
MexGen-COVID_AMR2305060
POLISH_COVID_WGS_EUR2241005
SCOURGE_EUR112413224
SweCovid_EUR1813748
UKBB_EUR680419851
genomicc_AFR4401336
genomicc_EAS274352
genomicc_EUR598941384
genomicc_SAS7883698
JSA-COVID19_EAS991193
Downloads
A2_ALL_afr_leave_23andme

Phenotype

Very severe respiratory confirmed covid vs. population

Population

afr

Total Cases

628

Total Controls

12568

Contributing Studies
Namen_casesn_controls
CU_AFR1332610
PMBB_AFR558622
genomicc_AFR4401336
Downloads
A2_ALL_eas_leave_23andme

Phenotype

Very severe respiratory confirmed covid vs. population

Population

eas

Total Cases

794

Total Controls

4862

Contributing Studies
Namen_casesn_controls
JapanTaskForce_EAS4213317
genomicc_EAS274352
JSA-COVID19_EAS991193
Downloads
A2_ALL_eur_leave_23andme

Phenotype

Very severe respiratory confirmed covid vs. population

Population

eur

Total Cases

13769

Total Controls

1072442

Contributing Studies
Namen_casesn_controls
ANCESTRY_Freeze_Four_EUR667113882
Amsterdam_UMC_COVID_study_group_EUR661413
CU_EUR2032149
FinnGen_FIN190278193
GENCOVID_EUR10772443
GHS_Freeze_145_EUR321108168
SPGRX_EUR101302
Vanda_EUR58900
idipaz24genetics_EUR5975
BQC19_EUR2021366
BelCovid_EUR2971477
BioVU_EUR11768064
BoSCO_EUR195984
Charite_EUR87865
HOSTAGE_EUR185012226
INMUNGEN_CoV2_EUR81723
POLISH_COVID_WGS_EUR2241005
SCOURGE_EUR112413224
SweCovid_EUR1813748
UKBB_EUR680419851
genomicc_EUR598941384
Downloads
A2_ALL_his_leave_23andme

Phenotype

Very severe respiratory confirmed covid vs. population

Population

his

Total Cases

769

Total Controls

6209

Contributing Studies
Namen_casesn_controls
BRACOVID_AMR5391149
MexGen-COVID_AMR2305060
Downloads
A2_ALL_sas_leave_23andme

Phenotype

Very severe respiratory confirmed covid vs. population

Population

sas

Total Cases

980

Total Controls

47696

Contributing Studies
Namen_casesn_controls
GNH_SAS19243998
genomicc_SAS7883698
Downloads
B1_ALL_leave_23andme

Phenotype

Hospitalized covid vs. not hospitalized covid

Population

All

Total Cases

16512

Total Controls

71321

Contributing Studies
Namen_casesn_controls
CHOP_CAG_AFR147412
FHoGID_EUR470280
IranCovid_MID210183
BQC19_EUR654406
BelCovid_EUR504299
BioVU_EUR2851324
BoSCO_EUR425743
CCPM_EUR1891242
CGEN_EUR267307
ChiCovid_AMR143420
FinnGen_FIN4373105
GNH_SAS42343767
IND_GJ_COVID19_SAS411147
INMUNGEN_CoV2_EUR34765
JSA-COVID19_EAS4611193
MexCovid_AMR323198
PHBB_EUR318732
QGP_MID1911865
SCOURGE_EUR59343355
UCLA_AMR166405
UCLA_EUR150696
UKBB_AFR137286
UKBB_CSA172482
UKBB_EUR37489409
Downloads
B2_ALL_leave_23andme

Phenotype

Hospitalized covid vs. population

Population

All

Total Cases

44986

Total Controls

2356386

Contributing Studies
Namen_casesn_controls
ANCESTRY_Freeze_Four_AFR1355688
ANCESTRY_Freeze_Four_AMR19912323
ANCESTRY_Freeze_Four_EUR1484113882
Amsterdam_UMC_COVID_study_group_EUR1081413
BRACOVID_AMR853835
CU_AFR3042610
CU_EUR4532149
Corea_EAS696500
DECODE_EUR89274322
EstBB_EUR352196455
GENCOVID_EUR12872443
GHS_Freeze_145_EUR773108168
Generation_Scotland_EUR55418683
LGDB_EUR571531
MVP_AFR130098129
MVP_AMR51743062
MVP_EUR2417366449
PMBB_AFR1268551
SPGRX_EUR311302
idipaz24genetics_EUR10675
ArmCovid_OTH175160
BQC19_EUR654914
BelCovid_EUR5051477
BioVU_EUR28568064
BoSCO_EUR425984
CCPM_EUR18925696
COMRI_EUR120333
Charite_EUR198865
ChiCovid_AMR143522
FinnGen_FIN437337685
FrenchCovid_EUR456982
Genetics_COVID19_Korea_EAS93219672
HOSTAGE_EUR311712483
INMUNGEN_CoV2_EUR347723
Ioannina_EUR321852
JapanTaskForce_EAS9983317
JorCovid_MID523529
KazCovid_EAS148166
MexGen-COVID_AMR8765060
PHBB_EUR31831558
POLISH_COVID_WGS_EUR359871
PakCovid_CSA180174
QGP_MID19113868
SCOURGE_EUR59348810
UCLA_AMR1664686
UCLA_EUR15021234
UKBB_AFR1376499
UKBB_CSA1728704
UKBB_EUR3748416783
CHOP_CAG_AFR147412
FHoGID_EUR470280
IranCovid_MID210183
CGEN_EUR267307
GNH_SAS42343767
IND_GJ_COVID19_SAS411147
JSA-COVID19_EAS4611193
MexCovid_AMR323198
SaudiHumanGenomeProgram_ARAB147768
Vanda_EUR58900
Egypt_hgCOVID_hub_MID699472
SweCovid_EUR1813748
genomicc_AFR4401336
genomicc_EAS274352
genomicc_EUR598941384
genomicc_SAS7883698
Downloads
B2_ALL_afr_leave_23andme

Phenotype

Hospitalized covid vs. population

Population

afr

Total Cases

2589

Total Controls

123225

Contributing Studies
Namen_casesn_controls
ANCESTRY_Freeze_Four_AFR1355688
CU_AFR3042610
MVP_AFR130098129
PMBB_AFR1268551
UKBB_AFR1376499
CHOP_CAG_AFR147412
genomicc_AFR4401336
Downloads
B2_ALL_eas_leave_23andme

Phenotype

Hospitalized covid vs. population

Population

eas

Total Cases

2882

Total Controls

31200

Contributing Studies
Namen_casesn_controls
Corea_EAS696500
Genetics_COVID19_Korea_EAS93219672
JapanTaskForce_EAS9983317
KazCovid_EAS148166
JSA-COVID19_EAS4611193
genomicc_EAS274352
Downloads
B2_ALL_eur_leave_23andme

Phenotype

Hospitalized covid vs. population

Population

eur

Total Cases

32519

Total Controls

2062805

Contributing Studies
Namen_casesn_controls
ANCESTRY_Freeze_Four_EUR1484113882
Amsterdam_UMC_COVID_study_group_EUR1081413
CU_EUR4532149
DECODE_EUR89274322
EstBB_EUR352196455
GENCOVID_EUR12872443
GHS_Freeze_145_EUR773108168
Generation_Scotland_EUR55418683
LGDB_EUR571531
MVP_EUR2417366449
SPGRX_EUR311302
idipaz24genetics_EUR10675
BQC19_EUR654914
BelCovid_EUR5051477
BioVU_EUR28568064
BoSCO_EUR425984
CCPM_EUR18925696
COMRI_EUR120333
Charite_EUR198865
FinnGen_FIN437337685
FrenchCovid_EUR456982
HOSTAGE_EUR311712483
INMUNGEN_CoV2_EUR347723
Ioannina_EUR321852
PHBB_EUR31831558
POLISH_COVID_WGS_EUR359871
SCOURGE_EUR59348810
UCLA_EUR15021234
UKBB_EUR3748416783
FHoGID_EUR470280
CGEN_EUR267307
Vanda_EUR58900
SweCovid_EUR1813748
genomicc_EUR598941384
Downloads
B2_ALL_his_leave_23andme

Phenotype

Hospitalized covid vs. population

Population

his

Total Cases

3077

Total Controls

66686

Contributing Studies
Namen_casesn_controls
ANCESTRY_Freeze_Four_AMR19912323
BRACOVID_AMR853835
MVP_AMR51743062
ChiCovid_AMR143522
MexGen-COVID_AMR8765060
UCLA_AMR1664686
MexCovid_AMR323198
Downloads
B2_ALL_sas_leave_23andme

Phenotype

Hospitalized covid vs. population

Population

sas

Total Cases

1622

Total Controls

47612

Contributing Studies
Namen_casesn_controls
GNH_SAS42343767
IND_GJ_COVID19_SAS411147
genomicc_SAS7883698
Downloads
C2_ALL_leave_23andme

Phenotype

Covid vs. population

Population

All

Total Cases

159840

Total Controls

2782977

Contributing Studies
Namen_casesn_controls
ACCOuNT_AFR57799
ANCESTRY_Freeze_Four_AFR16295688
ANCESTRY_Freeze_Four_AMR375212323
ANCESTRY_Freeze_Four_EAS120570
ANCESTRY_Freeze_Four_EUR25353113882
CU_AFR3322610
CU_EUR5082149
Corea_EAS1086500
Coronagenes_EUR181734
EXCEED_EUR2361083
EstBB_EUR4070189406
GENCOVID_EUR16972443
GFG_EUR1364978
GHS_Freeze_145_AFR1283050
GHS_Freeze_145_AMR881307
GHS_Freeze_145_EUR5276108168
Generation_Scotland_EUR171217525
HUNT_EUR28352072
LGDB_EUR2751313
Lifelines_EUR89526600
MGI_EUR12251458
MGI_AFR1112989
MOBA_EUR39156038
MVP_AFR489394556
MVP_AMR249741100
MVP_EUR11778357198
NTR_EUR2285265
PMBB_AFR3798298
PMBB_EUR609702
SPGRX_EUR362302
Stanford_EUR169190
TOPMed_CHRIS10K_EUR922373
TOPMed_Gardena_EUR452458
WGHS_EUR22511887
genomicsengland100kgp_EUR82244369
genomicsengland100kgp_SAS2354205
thaicovid_EAS191113
ABCD_EUR2343135
ALSPAC_G1_EUR5234199
BQC19_EUR1060508
BelCovid_EUR8041477
BioVU_EUR159268064
BoSCO_EUR1168984
CCHC_HIS1963039
CCPM_AMR3203074
CCPM_EUR149624389
ChiCovid_AMR705522
DBDS_EUR555487127
ERACORE_EUR2101547
Egypt_hgCOVID_hub_MID710472
FinnGen_FIN4814337685
GCAT_EUR7104278
GNH_SAS792236268
Genotek_EUR695918720
HOSTAGE_EUR309710327
Helix_EUR105510960
INMUNGEN_CoV2_EUR412723
JapanTaskForce_EAS24333317
JorCovid_MID529529
MexGen-COVID_AMR9395060
PHBB_AFR1601909
PHBB_AMR2701970
PHBB_EUR105931558
POLISH_COVID_WGS_EUR235998
QGP_MID205612003
SCOURGE_EUR93015455
SINAI_COVID_AFR74143
SINAI_COVID_AMR128123
SINAI_COVID_EUR13298940
TIKOCO_EUR5723436
UCLA_AFR1521585
UCLA_AMR5714281
UCLA_EAS1402835
UCLA_EUR84620538
UKBB_AFR4596177
UKBB_AMR58922
UKBB_CSA7358141
UKBB_EAS1132596
UKBB_EUR14539405992
UKBB_MID971502
INTERVAL_EUR209839733
Amsterdam_UMC_COVID_study_group_EUR1081413
BRACOVID_AMR853835
DECODE_EUR89274322
idipaz24genetics_EUR10675
ArmCovid_OTH175160
COMRI_EUR120333
Charite_EUR198865
FrenchCovid_EUR456982
Genetics_COVID19_Korea_EAS93219672
Ioannina_EUR321852
KazCovid_EAS148166
PakCovid_CSA180174
SaudiHumanGenomeProgram_ARAB147768
Vanda_EUR58900
SweCovid_EUR1813748
genomicc_AFR4401336
genomicc_EAS274352
genomicc_EUR598941384
genomicc_SAS7883698
Downloads
C2_ALL_afr_leave_23andme

Phenotype

Covid vs. population

Population

afr

Total Cases

8814

Total Controls

129140

Contributing Studies
Namen_casesn_controls
ACCOuNT_AFR57799
ANCESTRY_Freeze_Four_AFR16295688
CU_AFR3322610
GHS_Freeze_145_AFR1283050
MGI_AFR1112989
MVP_AFR489394556
PMBB_AFR3798298
PHBB_AFR1601909
SINAI_COVID_AFR74143
UCLA_AFR1521585
UKBB_AFR4596177
genomicc_AFR4401336
Downloads
C2_ALL_eas_leave_23andme

Phenotype

Covid vs. population

Population

eas

Total Cases

4459

Total Controls

36121

Contributing Studies
Namen_casesn_controls
ANCESTRY_Freeze_Four_EAS120570
Corea_EAS1086500
thaicovid_EAS191113
JapanTaskForce_EAS24333317
UCLA_EAS1402835
UKBB_EAS1132596
Genetics_COVID19_Korea_EAS93219672
KazCovid_EAS148166
genomicc_EAS274352
Downloads
C2_ALL_eur_leave_23andme

Phenotype

Covid vs. population

Population

eur

Total Cases

122616

Total Controls

2475240

Contributing Studies
Namen_casesn_controls
ANCESTRY_Freeze_Four_EUR25353113882
CU_EUR5082149
Coronagenes_EUR181734
EXCEED_EUR2361083
EstBB_EUR4070189406
GENCOVID_EUR16972443
GFG_EUR1364978
GHS_Freeze_145_EUR5276108168
Generation_Scotland_EUR171217525
HUNT_EUR28352072
LGDB_EUR2751313
Lifelines_EUR89526600
MGI_EUR12251458
MOBA_EUR39156038
MVP_EUR11778357198
NTR_EUR2285265
PMBB_EUR609702
SPGRX_EUR362302
Stanford_EUR169190
TOPMed_CHRIS10K_EUR922373
TOPMed_Gardena_EUR452458
WGHS_EUR22511887
genomicsengland100kgp_EUR82244369
ABCD_EUR2343135
ALSPAC_G1_EUR5234199
BQC19_EUR1060508
BelCovid_EUR8041477
BioVU_EUR159268064
BoSCO_EUR1168984
CCPM_EUR149624389
DBDS_EUR555487127
ERACORE_EUR2101547
FinnGen_FIN4814337685
GCAT_EUR7104278
Genotek_EUR695918720
HOSTAGE_EUR309710327
Helix_EUR105510960
INMUNGEN_CoV2_EUR412723
PHBB_EUR105931558
POLISH_COVID_WGS_EUR235998
SCOURGE_EUR93015455
SINAI_COVID_EUR13298940
TIKOCO_EUR5723436
UCLA_EUR84620538
UKBB_EUR14539405992
INTERVAL_EUR209839733
Amsterdam_UMC_COVID_study_group_EUR1081413
DECODE_EUR89274322
idipaz24genetics_EUR10675
COMRI_EUR120333
Charite_EUR198865
FrenchCovid_EUR456982
Ioannina_EUR321852
Vanda_EUR58900
SweCovid_EUR1813748
genomicc_EUR598941384
Downloads
C2_ALL_his_leave_23andme

Phenotype

Covid vs. population

Population

his

Total Cases

10377

Total Controls

74556

Contributing Studies
Namen_casesn_controls
ANCESTRY_Freeze_Four_AMR375212323
GHS_Freeze_145_AMR881307
MVP_AMR249741100
CCHC_HIS1963039
CCPM_AMR3203074
ChiCovid_AMR705522
MexGen-COVID_AMR9395060
PHBB_AMR2701970
SINAI_COVID_AMR128123
UCLA_AMR5714281
UKBB_AMR58922
BRACOVID_AMR853835
Downloads
C2_ALL_sas_leave_23andme

Phenotype

Covid vs. population

Population

sas

Total Cases

8945

Total Controls

44171

Contributing Studies
Namen_casesn_controls
genomicsengland100kgp_SAS2354205
GNH_SAS792236268
genomicc_SAS7883698
Downloads